解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits of TMP are largely attributed to its anti-oxidative and vasodilative properties. However, the effica...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3770-0
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3849-7
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Automatic tendencies to approach drug-related cues have been linked to the development and maintainance of harmful drug-taking behavior. Recent studies have demonstrated that these automatic approach tendencies can be targeted directly by means of cognitive bias modification (CBM). Moreover, changing those a...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3835-0
更新日期:2019-12-12 00:00:00
abstract::After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. We would like to formally apologize and give credit to the authors of that article [2]: Chris Smith, Uk Vannak, Ly Sokhey, Thoai D Ngo, Judy Gold, Khemrin Khut,...
journal_title:Trials
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13063-019-3941-z
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:Medically unexplained symptoms (MUS) are highly prevalent and pose a burden both on patients and on health care. In a pilot study psychosomatic therapy delivered by specialised therapists for patients with MUS showed promising results with regard to patient's acceptability, feasibility and effects on symptom...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3913-3
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupunc...
journal_title:Trials
pub_type: 杂志文章,多中心研究
doi:10.1186/s13063-019-3744-2
更新日期:2019-12-04 00:00:00
abstract:BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3733-5
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) is a chronic, degenerative disease of the central nervous system. Because of the long-term and unpredictable nature of the disease, the burden of MS is significant from both a patient and societal perspective. Despite a recent influx of disease-modifying therapies to treat MS, many in...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3768-7
更新日期:2019-12-02 00:00:00
abstract:BACKGROUND:Hospital mortality for patients with sepsis has recently declined, but sepsis survivors still suffer from significant long-term mortality and morbidity. There are limited data that support effective strategies to address post-discharge management of patients hospitalized with sepsis. METHODS:The Improving M...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3792-7
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3689-5
更新日期:2019-11-20 00:00:00
abstract:BACKGROUND:This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a university hospital for patients with frequent episodic or chronic tension-type headach...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3700-1
更新日期:2019-11-08 00:00:00
abstract:BACKGROUND:Acute mountain sickness (AMS) is a cluster of symptoms that commonly occur in those ascending to high altitudes. Symptoms can include headaches, nausea, insomnia and fatigue. Exposure to high altitude can also lead to high-altitude cerebral oedema (HACE), which is a potential cause of death whilst mountainee...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3681-0
更新日期:2019-10-24 00:00:00
abstract:BACKGROUND:Fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease, and calcimimetic therapy reduces plasma concentrations of FGF23. It remains unknown whether treatment with the calcimimetic etelcalcetide (ETL) reduces LVH in patients on hemodia...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3707-7
更新日期:2019-10-24 00:00:00
abstract::Following publication of the original article [1], we have been notified of a few mistakes in the "Sample size calculations" section, second paragraph. ...
journal_title:Trials
pub_type: 已发布勘误
doi:10.1186/s13063-019-3771-z
更新日期:2019-10-16 00:00:00
abstract:BACKGROUND:Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to support a bacterial infection, promoting the emergence of multidrug-resistant organisms. Moreover, the ben...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3675-y
更新日期:2019-10-15 00:00:00
abstract:RATIONALE:In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3641-8
更新日期:2019-10-11 00:00:00
abstract:BACKGROUND:The World Health Organization recommended (in 2010) universal testing for suspected malaria, due to some fundamental changes in malaria trends such as the declining incidence of malaria in high-burden countries, the emergence of parasite resistance to anti-malarial drugs especially artemisinin-based combinat...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3620-0
更新日期:2019-10-10 00:00:00
abstract:BACKGROUND:Tobacco smoking is a highly prevalent, addictive behaviour and a key public health priority. However available cessation therapies have low quit and high relapse rates, indicating an urgent need for more effective treatments. Predicated on promising preclinical and pilot clinical data, this paper presents a ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3628-5
更新日期:2019-09-10 00:00:00
abstract:BACKGROUND:Adverse events (AEs) in clinical trials may be reported in multiple sources. Different methods for reporting adverse events across trials or across sources for a single trial may produce inconsistent information about the adverse events associated with interventions. METHODS:We compared the methods authors ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3581-3
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Cigarette smoking negatively impacts on maternal and fetal health. Smoking cessation is one of the few interventions capable of improving pregnancy outcomes. Despite the risks, the most effective antenatal model of care for smokers is still unclear, and specific recommendations for screening for fetal growth...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3653-4
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their general practitioner (GP) in the first instance, with conse...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3648-1
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might be a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented in Shanghan Lun, has been used for treating severe sepsis for thousands of years. Research shows that it may h...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3646-3
更新日期:2019-08-28 00:00:00
abstract:BACKGROUND:Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elder...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3607-x
更新日期:2019-08-20 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) is one of the most common types of the cardiovascular disease. Previous pilot trials have suggested that Traditional Chinese Medicine (TCM) has brought clinical benefits for patients with CAD. We will conduct this trial to determine the efficacy and safety of Shenzhu Guanxin Rec...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3629-4
更新日期:2019-08-20 00:00:00
abstract::There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-019-3627-6
更新日期:2019-08-19 00:00:00
abstract:BACKGROUND:Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. OBJECTIVE:To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postme...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3575-1
更新日期:2019-08-16 00:00:00
abstract:BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3585-z
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Recurrent stroke is a major contributor to stroke-related disability and costs. Improving health-risk behaviours and mental health has the potential to significantly improve recovery, enhance health-related quality of life (HRQoL), independent living, and lower the risk of recurrent stroke. The primary aim w...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3604-0
更新日期:2019-08-09 00:00:00
abstract:BACKGROUND:South Africa is among the seven highest tuberculosis (TB) burden countries. Harmful lifestyle behaviours, such as smoking and alcohol, and poor adherence to medication can affect clinical outcomes. Modification of these behaviours is likely to improve TB treatment outcomes and has proven possible using motiv...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3551-9
更新日期:2019-07-26 00:00:00
abstract:BACKGROUND:Spine surgery is associated with considerable postoperative pain and can be challenging to treat. A loco-regional technique suitable for spine surgery should cover the dorsal root of the spinal nerves at the levels where surgery is performed. The erector spinae block is a loco-regional technique with promisi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3541-y
更新日期:2019-07-17 00:00:00
abstract:INTRODUCTION:End-of-life (EoL) care professionals are prone to burnout given the intense emotional nature of their work. Previous research supports the efficacy of art therapy in reducing work-related stress and enhancing emotional health among professional EoL caregivers. Integrating mindfulness meditation with art th...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3533-y
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3492-3
更新日期:2019-07-02 00:00:00
abstract:BACKGROUND:It is widely agreed that triglyceride (TG)-lowering therapy is imperative in early hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Intravenous insulin with or without heparin, and plasmapheresis are available regimens. However, there is no consensus on first-line therapy. METHODS/DESIGN:The Bi-TPA...
journal_title:Trials
pub_type: 杂志文章,多中心研究
doi:10.1186/s13063-019-3498-x
更新日期:2019-06-18 00:00:00
abstract:INTRODUCTION:Psoriasis vulgaris is a common skin disease characterized by persistent localized erythematous scaly plaques, typically on the elbows, knees, and scalp. It is an immune-abnormal disease that progresses slowly over a long period with frequent symptom recurrence. Current studies have shown that acupuncture i...
journal_title:Trials
pub_type: 杂志文章,多中心研究
doi:10.1186/s13063-019-3475-4
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This stud...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3429-x
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:Radical lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is surgically demanding and can be associated with substantial postoperative morbidity. The question of whether robot-assisted esophagectomy (RE) might be superior to video-assisted thoracoscopic esophagectomy (VATE) for perfo...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3441-1
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:Earlier vascular healing after drug-eluting stent (DES) implantation may reduce the incidence of late stent thrombosis and provide theoretical evidence to shorten dual antiplatelet therapy duration in patients with high bleeding risks. The BuMA supreme stent is a newly developed DES-coated with the sirolimus...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3361-0
更新日期:2019-06-07 00:00:00
abstract:BACKGROUND:The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum toe clearance (MTC) is the key gait cycle event for predicting tripping-falls because it occurs mid-swing during the walking c...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3404-6
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:Nursing home residents are frequently affected by joint contractures, which impacts their participation and daily activities. A complex intervention, the Participation Enabling Care in Nursing (PECAN), was previously developed and pilot tested to address their needs. Its effectiveness and safety will be eval...
journal_title:Trials
pub_type: 杂志文章,多中心研究
doi:10.1186/s13063-019-3384-6
更新日期:2019-05-29 00:00:00
abstract:BACKGROUND:Three-dimensional (3D) stereoscopic vision is crucial to perform any kind of manual task. The reduction from real life 3D to virtual two-dimensional (2D) sight is a major challenge in minimally invasive surgery (MIS). A 3D display technique has been shown to reduce operation time and mistakes and to improve ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3330-7
更新日期:2019-05-28 00:00:00